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Anti-inflammatory drugs are helpful during the symptomatic thrombosis-related episodes. Cyclooxygenase-2 (COX-2) inhibitors (such as Celebrex) have also proved to be effective against pain. Low-molecular-weight heparin may also be used to decrease the disseminated intravascular consumption and is recommended in the preoperative preparation prior to resection. Corticosteroids, interferon, and other antiangiogenic drugs have proven useless in the treatment of venous malformations. 2 Sclerotherapy Sclerotherapy, with or without surgery, is the treatment of choice for symptomatic venous malformations.