By Bernd-Dietrich Katthagen
Congenital and bought bone defects represent a critical challenge of traumatology and orthopedics. with a view to therapy those defects it's always essential to refill the bones operatively with appropriate ingredients. lately, so-called bone substitutes (collagen, gelatine, bone matrix, calcium phospate, hydroxyapatite) have additionally been instructed. Following an introductory presentation of bone regeneration and transplants, those substitutes are mentioned right here in a finished survey of the literature. specific recognition is given to the importance of mineral substance comparable to hydroxyapatite, on the way to absolutely discover a position in bone surgical procedure due to its notable bioactivity and biotolerance. The implants tested also are of importance for maxillofacial surgical procedure and dentistry. The histologic thoughts within the staining of undecalcified bone arrangements and in histomorphometry are offered in a distinct chapter.
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Extra resources for Bone Regeneration with Bone Substitutes: An Animal Study
Other authors subsequently also worked with decalcified allogenic bone matrix. Narang and Wells (1973) implanted this material into the root cavity of the tooth and also observed stimulation of osteogenesis. Plasmans et al. (1978) used decalcified allogenic bone matrix for ectopic bone induction in rabbit back muscles, and observed inhibition of this ectopic osteogenesis under the influence of diphosphonate. After withdrawal of diphosphonate, bone formation started again. Tuli and Singh (1978) filled bony and periosteal resection defects in the rabbit ulna diaphysis with decalcified allogenic bone matrix.
In 1934, Haldemann and Moore repeated the above experiments with injections of different calcium phosphates, and discussed the literature which had appeared in the meantime. Eden (1923, quoted by Haldemann and Moore 1934) could not obtain favourable results with either calcium phosphate or calcium carbonate, which he used to fill resected defects in the rabbit. In contrast, Cretin (1924, quoted by Haldemann and Moore 1934) found faster bone regeneration with injections of various minerals. 5 cm bone gap in the dog radius with sterile calcium-carbonate powder and calcium phosphate.
Eden (1923, quoted by Haldemann and Moore 1934) could not obtain favourable results with either calcium phosphate or calcium carbonate, which he used to fill resected defects in the rabbit. In contrast, Cretin (1924, quoted by Haldemann and Moore 1934) found faster bone regeneration with injections of various minerals. 5 cm bone gap in the dog radius with sterile calcium-carbonate powder and calcium phosphate. Rollo (1931, quoted by Haldemann and Moore 1934) observed faster bone healing in the rabbit with calcium glycerine-phosphate.