By Nancy Y. Ip, Li-Huei Tsai
Cyclin established Kinase five presents a entire and up to date number of stories at the discovery, signaling mechanisms and capabilities of Cdk5, in addition to the aptitude implication of Cdk5 within the therapy of neurodegenerative illnesses. because the id of this particular member of the Cdk kinfolk, Cdk5 has emerged as probably the most vital sign transduction mediators within the improvement, upkeep and fine-tuning of neuronal capabilities and networking. additional reviews have printed that Cdk5 is usually linked to the law of neuronal survival in the course of improvement in addition to in neurodegenerative illnesses. those observations point out that targeted keep watch over of Cdk5 is key for the legislation of neuronal survival. The pivotal function that Cdk5 looks to play in either the legislation of neuronal survival and synaptic capabilities therefore increases the attention-grabbing probability that Cdk5 inhibitors can have healing strength for the therapy of a few neurodegenerative diseases.
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We prepared a rabbit polyclonal antibody, anti-pS522CRMP1/2 antibody, that recognized CRMP1 and CRMP2 phosphorylated at Ser522 in vitro, but not CRMP3, CRMP4, and CRMP5. Immunoblot analysis using anti-pS522-CRMP1/2 antibody revealed that the bands were at low intensity or were missing in lysate of embryonic brains from cdk5 / when compared to wild-type mice. During a search for in vivo substrate of Cdk5 using cdk5 / mice and a monoclonal antibody, which recognized phospho-threonine followed by proline (pThr-Pro antibody), Ohshima and his colleagues found that the threonine CRMP Family Protein: Novel Targets for Cdk5 15 phosphorylation was not seen with brain lysate from cdk5 / mice.
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