By Mark A. Herbert, Derek W. Hood, E. Richard Moxon
In HaemophilusiInfluenzae Protocols, top study scientists and infectious ailment experts aspect in a conveniently reproducible layout the most important molecular and immunological suggestions for exploring the pathogenicity of H. influenzae. defined with step-by-instructions to make sure powerful and winning experimental effects, the options hide plasmid research, proteomics, genomics, DNA array know-how, gene expression, mutagenesis (transposon and nontransposon), and structural research. those tools light up how the bacterium motives sickness, in addition to how top to improve novel vaccines and antibiotics opposed to the organism.
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Extra info for Hemophilus Influenzae Protocols (Methods in Molecular Medicine)
Eijk, P. , van Ham, S. , Jansen, H. , and van Alphen, J. (1998) The fimbria gene cluster of nontypeable Haemophilus influenzae. Infect. Immun. 66, 406–417. 71. , Smith, A. , and Golomb, M. (1998) Evolution of the major pilus gene cluster of Haemophilus influenzae. J. Bacteriol. 180, 4693–4703. 72. McCrea, K. , Watson, W. , Gilsdorf, J. , and Marrs, C. F. (1997) Identification of two minor subunits in the pilus of Haemophilus influenzae. J. Bacteriol. 179, 4227–4231. 73. Pichichero, M. , and Smith, D.
Sci. USA 96, 1077–1082. , Whitby, P. , Morton, D. , and Stull, T. L. (1999) Role of CCAA nucleotide repeats in regulation of hemoglogin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae. J. Bacteriol. 181, 5865–5870. Murphy, T. F. and Bartos, L. C. (1988) Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect. Immun. 56, 2673–2679. Forbes, K. , Bruce, K. , and Pennington, T. H. (1992) Variation in length and sequence of porin (ompP2) alleles of non-encapsulated Haemophilus influenzae.
It has been shown that more than 90% of a population of H. influenzae cells inoculated intravascularly (iv) into the adult rat are cleared within a few minutes (48). Interestingly, it was shown that the remaining subpopulation that evaded clearance replicated sufficiently to invade the meninges of the rat and cause meningitis (48). Factors that aid the survival of subpopulations or variants of H. influenzae in the bloodstream are discussed later in this chapter. The clearance of encapsulated H.