By F. Schajowicz (auth.)
This new version displays advances within the analysis and class of bone tumours revamped the twenty years because the first variation seemed. even supposing nonetheless in accordance with regimen gentle microscopy, the revised classificationbenefits from immunohistochemical and molecular organic findings. It discusses new entities, reminiscent of intraosseous good differentiated osteosarcoma, round-cell osteosarcoma, and clear-cell chondrosarcoma. It bargains with the problems of prognosis in the crew of malignant roundcell tumours, reminiscent of the excellence among Ewing sarcoma and primitive neuroectodermal tumour of bone. those alterations replace the class to facilitate the comparability of information either nationally and the world over.
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Extra resources for Histological Typing of Bone Tumours
2 Lipoma A benign tumour of mature adipose tissue with no evidence of cellular atypia. There are two types of lipoma, an intraosseous and a periosteal type, the latter usually inducing new bone formation. Although these lesions constitute an established entity, they are rare. They usually occur in adults, and may be mistaken for other more serious types of lesions, or may be associated with a bone infarct. A variety of skeletal sites are involved, most commonly long bones and calcaneus. Angiolipomatous malformations, usually ofthe vertebral bodies, have been described, but they should be distinguished from true lipomas.
129-131) A malignant tumour characterized by the formation by the tumour cells of interlacing bundles of collagen fibres, and by the absence of other types of histological differentiation, such as cartilage or bone. Fibrosarcomas of bone were originally classified with osteosarcomas, but the view that they should be regarded as a separate group has become generally accepted. Fibrosarcomas usually involve long bones, particularly the lower part of the femur and the upper part of the tibia. They occur in older patients than do osteosarcomas, mostly in persons from 20 to 60 years of age.
Angiosarcomas of bone are rare, and it must be emphasized that other highly vascular tumours, particularly the relatively common telangiectatic osteosarcoma, are sometimes erroneously diagnosed as angiosarcoma. A positive immunocytochemical reaction for factor VIn or for Ulex lectin can be useful in identifying the vascular nature of a poorly differentiated malignant tumour. Angiosarcomas are highly malignant tumours that metastasize rapidly to the lungs. Multiple angiosarcomas of bone, or of bone and soft tissues, can occur.