By Regina Murphy (Editor), Amos Tsai (Editor)
This article offers an updated number of theoretical and experimental stories into protein folding, misfolding, aggregation, and balance. also, concerns confronted throughout the improvement of protein items are illustrated. It includes an introductory bankruptcy for readers new to the protein folding box. The e-book offers an intensive and transparent dialogue of computational techniques to realizing and modeling protein aggregation.
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Additional resources for Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability
The kinetics of monomer loss, rather than aggregate buildup, therefore are the primary focus here. On a related point, high precision light-scattering techniques also may be used to quantitate aggregation kinetics,16,28 and provide much greater sensitivity in detection of aggregates than do typical chromatographic methods. From a modeling perspective, both types of data have advantages. Analysis of monomer loss kinetics can be simpler than that for aggregate accumulation kinetics, as one is able to take advantage of the highly mono-disperse nature of monomeric proteins.
J. 26 d[M] 2 [M]2 − = −2k D,D f D,eq dt n ∗ −1 k1, j [A j ] f D,eq [M] (26) j=2 ∗ n −1 d[A2 ] 2 [M]2 − k1,2 f D,eq [A2 ][M] − k2, j [A2 ][A j ] = k D,D f D,eq dt j=3 −2k2,2 [A2 ]2 d[Ai ] dt (27) i/2 i 56) it follows that E obs at lower T will be given by E obs |T
56) it follows that E obs at lower T will be given by E obs |T