By Cyril H. Wecht, Glenn M. Larkin (auth.), J. K. Mason CBE, MD, LLD, FRCPath, DMJ (eds.)
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Extra resources for Paediatric Forensic Medicine and Pathology
After the male at III, 1, is diagnosed, the history of the maternal uncle II, 2, having died of the disease is discovered. DNA studies of polymorphisms on the X chromosome close to the disease locus show that the affected boy's mother is heterozygous for two marker systems which are both within 1% or so of the abnormal gene. These systems have been named the 'AB' system and the 'CD' system for simplicity, but often there are more than two possible alleles at the marker locus. Since the affected boy has the A marker and the C marker it can be assumed that these markers are both on the same X chromosome and that they are on the X chromosome that contains the defective gene.
Most drug abusers use multiple drugs, and the majority of pregnant women have little insight into the extent or significance of their drug taking during early pregnancy . The organizers of a voluntary methadon e programm e involving 13 pregnant morphine addicts, who had a close relationsh ip with their medical caretakers, tested urine samples from the patients during their treatment; the drug screens disclosed that four women were concomitantly using benzodiaz epines and that one was positive for amphetam ines .
Invest. , 17, 475. 7. A. S. (1985) Prenatal diagnosis by chorion villus 23. sampling: lessons of the first 600 cases. Prenatal Diag. , 5, 393. 24. 8. S. ) (1987) Abortion in Debate, St Andrew Press, Edinburgh. 9. Scottish Home and Health Department (1987) 25. Abortion statistics. Health Bull. ), 45,277. Scotland: Report of a Working Party of the National 10. OPCS (1987), Abortion Statistics 1986, Series AB, Medical Consultative Committee, Scottish Home No. 13, HMSO, London. and Health Department.