By A.P. Simopoulos, J.A. Milner, B. Koletzko
Wisdom of the impression of our genetic edition to nutritional reaction (nutrigenetics) and the way food may perhaps have an effect on gene expression (nutrigenomics) is prompting a revolution within the box of foodstuff. Nutrigenetics/Nutrigenomics offer robust methods to solve the advanced relationships between dietary molecules, genetic versions and the organic process. This e-book includes chosen papers from the '3rd Congress of the foreign Society of Nutrigenetics/Nutrigenomics' held in Bethesda, Md., in October 2009. The contributions handle frontiers in nutrigenetics, nutrigenomics, epigenetics, transcriptomics in addition to non-coding RNAs and posttranslational gene rules in a variety of ailments and stipulations. as well as clinical reviews, the demanding situations and possibilities dealing with governments, academia and the are incorporated. everybody attracted to the way forward for customized drugs and nutrients or agriculture, in addition to researchers in academia, executive and will locate this ebook of the maximum curiosity for his or her paintings.
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Additional info for Personalized nutrition: Translating nutrigenetic nutrigenomic research into dietary guidelines
This study complemented other research that found that carriers of the G variant allele (–219G→T) of the APOE gene specifically reduced insulin resistance when fed a diet rich in monounsaturated fatty acids . Another study observed that a saturated fat load was associated with a greater elevation in postprandial triglycerides in the Thr54/Thr54 polymorphism of the FABP2 gene . On the other hand, an interaction between variants in PPARG and ADBR2 genes affecting eating behavior and body composition was found when a hypocaloric diet was prescribed .
11 genes (15 SNPs) Nieters, 2002 [12 ] n–6 PUFA Obesity risk A substantial elevation of obesity risk with increasing intake of n–6 fatty acids in carriers (1 or 2 alleles) of TNFα, leptin and PPARG variants. ADBR2 Martinez, 2003  CHO CHO/fat ratio BMI/ obesity risk Women with a high CHO intake (>49% VET) had greater risk of obesity in Gln27Gln heterozygotes. PPARG Memisoglu, 2003  Total fat MUFA BMI Intake of monounsaturated fat was inversely associated with BMI among 12 Ala variant carriers.
They pointed to differences between the genetic basis of disease in different ethnicities, and suggested that the information gathered should include consideration of behavior. Surprisingly, however, they failed to highlight the potential importance of diet and/or environment. Their 9 recommendations are reproduced in table 1. Celiac disease provides an example where Ng et al.  showed good agreement between direct-to-consumer testing companies. Celiac disease represents a major food intolerance, with a current prevalence rate of approximately 1 per 100 individuals in the population .