By Karla Loureiro Almeida, José Abreu, C. Y. Irene Yan (auth.), Henning Ulrich (eds.)
Stem cells are interesting phone varieties. they could mirror themselves ceaselessly whereas keeping the aptitude to generate progeny with speci?c services. as a result of those targeted homes, stem cells were matters of in depth research, from knowing simple mechanisms underlying tissue new release, to modeling human illnesses, to program for telephone substitute treatment. Stem cells are available in assorted kinds. for instance, mouse embryonic stem cells can normal all phone kinds in a physique, both in a dish or while placed again into mouse embryos. nevertheless, neural stem cells within the grownup mind generate neurons and glia cells that give a contribution to the brain’s plasticity. fast growth has been made within the stem mobile ?eld with discov- ies released in a list velocity. a brief Pubmed seek has lower back 2789 hits for “embryonic stem cells” and 815 hits for “adult neural stem cells/neurogenesis” within the yr 2008 by myself. It continues to be a taunting job for all who're attracted to stem cells to maintain with swiftly amassing literatures. The “Perspectives of Stem Cells” by means of a very overseas workforce of specialists presents a well timed and precious spotlight of the stem cellphone ?eld gearing towards destiny healing functions within the worried process. Stem cells with neural potentials have attracted loads of awareness as a result of their promise for phone substitute treatment, starting from degenerative neurological dis- ders to spinal twine injuries.
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Extra info for Perspectives of Stem Cells: From tools for studying mechanisms of neuronal differentiation towards therapy
Thus, astrocytes from the SGZ were able to generate the three main types of cells in the brain, exhibiting characteristics of multipotentiality of stem cell. Seaberg and Van der Kooy (2002), however, questioned whether the hippocampus could indeed contain stem cells. They speculated that the detection of stem cell in the primary precursor cell cultures derived from the hippocampus could in fact be due to stem cell contamination from the ventricular wall. It may also be possible that the discrepancy resulted from differences in cell culture and isolation protocols, leading to the enrichment of different cell population.
Nottebohm suggested that neurogenesis acts as source of neuronal replacement to keep neuronal circuits functionally young (Nottebohm, 2002). , 2004). In the hippocampus, new neurons are added to the existing networks and to the dentate gyrus throughout life. Epilepsy, of all the neurological disorders, is the only condition where there is evidence that more neurogenesis may act as to increase rather than merely replace dying neurons. , 1997). , 1999). , 2004; Covolan and Mello, 2000; Zhao and Overstreet-Wadiche, 2008).
Nat Neurosci 2:260–265. Gould E, Gross CG (2002) Neurogenesis in adult mammals: some progress and problems. J Neurosci 22:619–623. Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E (1997) Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 17:2492–2498. Gould E, Reeves AJ, Graziano MS, Gross CG (1999b) Neurogenesis in the neocortex of adult primates. Science 286:548–552. Gould E, Tanapat P (1997) Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat.