By Angel Garcia-Alonso, Yotis Senis
The aim of the ebook is to introduce platelets, and their practical position in thrombotic and heart problems, justifying the relevance of platelet proteomics examine. concentration then shifts to the hot advancements on mass spectrometry (MS)-based proteomics. This bankruptcy exhibits capability functions for platelet proteomics now not but carried out. It contains examples of post-translational ameliorations (PTMs) research in platelets.The moment a part of the booklet makes a speciality of the most learn performed thus far on platelet proteomics. This contains common proteome mapping by means of non-gel dependent separation tools (MudPit), research of the overall platelet proteome and signaling cascades by way of gel-based separation equipment (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). ultimately, the final part hyperlinks the platelet transcriptome and alertness to disease. This part is extremely proper and contains chapters on proteomics, transcriptomics, useful genomics, structures biology, and their functions to platelet-related ailments.
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Additional resources for Platelet Proteomics: Principles, Analysis, and Applications (Wiley - Interscience Series on Mass Spectrometry)
Foy M, Harney DF, Wynne K, Maguire PB, Enrichment of phosphotyrosine proteome of human platelets by immunoprecipitation, Methods. Mol. Biol . 357:313–318 (2007). 106. Zahedi RP, Begonja AJ, Gambaryan S, Sickmann A, Phosphoproteomics of human platelets: A quest for novel activation pathways, Biochim. Biophys. Acta 1764(12):1963–1976 (2006). 107. , Differential proteome analysis of TRAP-activated platelets: Involvement of DOK–2 and phosphorylation of RGS proteins, Blood 103(6):2088–2095 (2004). 108.
In the context of signaling proteins, compartmentalization brings molecules together to form the functional units of cell biology. 4. 14 THE IMPACT OF PROTEOMIC ANALYSIS The plasma membrane forms the interface between a cell and its environment and as such is crucial to the exchange of information with and response to the external environment (see Chapter 5). It is not surprising, then, that membrane proteins make up about 70% of the known protein targets for drugs  or that platelet surface proteins and transmembrane proteins have been the focus of several studies with the aim of discovering potential targets both for drug development and as biomarkers of disease [112,113,116,118].
21(8):1333–1339 (2001). 87. Libby P, The molecular mechanisms of the thrombotic complications of atherosclerosis, J. Intern. Med . 263(5):517–527 (2008). 88. , Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E, Nat. Med . 9(1):61–67 (2003). 22 THE IMPACT OF PROTEOMIC ANALYSIS 89. Gleissner CA, von Hundelshausen P, Ley K, Platelet chemokines in vascular disease, Arterioscler. Thromb. Vasc. Biol . 28(11):1920–1927 (2008). 90. May AE, Kalsch T, Massberg S, Herouy Y, Schmidt R, Gawaz M, Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells, Circulation 106(16):2111–2117 (2002).