By World Health Organization Editors
The toxicological monograph's during this quantity summarize the protection facts on a couple of foodstuff ingredients: Beeswax Candelilla wax Quillaia extract style 1 and a pair of Phospholipase from fusarium venenatum expressed in Aspergillus oryzae Calcium L-5 methyltetrahydrofolate (L-5_MTHF) and Pulllulan (Pullulan P1-20). Monograph's on seven teams of similar flavouring brokers evaluated via the strategy for the security review of Flavouring brokers also are integrated.
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Additional resources for Safety Evaluation of Certain Food Additives (Who Food Additives Series) WHO Food Additives Series, No 56
Sperm count, motility, direct progressive movement and sperm head abnormalities were assessed. Water consumption was significantly reduced in the 500 mg/l group, although body weights were unaffected. No other treatmentrelated effects were reported. A third study was carried out using three groups of male rats consuming 0, 10 or 100 mg sodium chlorite/l in their drinking-water. Observed fertility rates did not differ in a dose-dependent manner, and litter survival rates, mean litter size, median day of eye opening and observed vaginal patency were unaffected by the treatment.
A significant increase in reticulocytes was seen in the 15 mg/l group, but not in other groups. The number of CD8+ T cells was significantly increased in the highest treatment group. The total number of CD4+ T cells, B cells, natural killer (NK) cells and macrophages and the total number of spleen cells remained unaffected by treatment. Spleen immunoglobulin M (IgM) antibody response to T-dependent antigen from sheep erythrocytes was determined using a modified haemolytic plaque assay, and antibody forming cells (AFC) were counted and expressed as AFC/106 spleen cells or AFC/spleen.
Normal healthy adult male volunteers (10 per group) were given water containing no disinfectant or water containing chlorine dioxide, chlorite, chlorate, chlorine or chloramine at increasing concentrations over a series of six dosing periods of 3 days each. On the first day of each 3-day period, each volunteer ingested 1000 ml of dilute sodium chlorite solution in two portions taken 4 h apart. 4 mg/l on day 16. 034 mg/kg bw, respectively, expressed as chlorite. g. blood pressure, respiration rate, pulse and temperature).