By D. A. Christie, E. M. Tansey (Editors)
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Extra resources for Short-course Chemotherapy for Tuberculosis (Wellcome Witnesses to Twentieth Century Medicine Vol 24)
Were there any randomized controlled trials done on those two comparisons? Mitchison: The first trials were with streptomycin and PAS and streptomycin and isoniazid, weren’t they? Davies: No, they did streptomycin/isoniazid versus PAS/isoniazid, but not streptomycin/PAS, you see that was never included. Mitchison: That was a matter of great interest because streptomycin is not a very good drug, it’s only moderately good, whereas on the whole isoniazid is an excellent drug, and you see this on the very rare occasions when a comparison of that sort is made.
Jindani: I want to tell you about two completely different aspects of study R, which was the first short-course chemotherapy study that I had the privilege of coordinating in 42 centres in East Africa and Zambia. 65 Of course there were no 20-page consent forms to be signed, and it would have been difficult to get African patients with tuberculosis to sign a 20-page form; they might have signed it, but they might not have understood it. I did it this way: when they came to the hospital, I would say, ‘Look you have tuberculosis, if I give you treatment for 18 months, and you take it, you will be cured.
40 Crofton (1960). See also Ormerod and Prescott (2003). 41 Medical Research Council/Tuberculosis Chemotherapy Trials Committee (1962). 42 Spinaci (1990): 7–14. 11 Short-course Chemotherapy for Tuberculosis wonderful work in East Africa, producing short-course chemotherapy. I hope they will be able to tell us what the routine results in those countries were in their previous studies, and in the general population, and perhaps they can do that more accurately for Singapore and Hong Kong, both of which had good services, but I cannot give those figures.