By J. Silvio Gutkind
Prime scientists summarize the newest findings on sign transduction and mobilephone cycle rules and describe the trouble to layout and synthesize inhibiting molecules, in addition to to judge their biochemical and organic actions. They evaluation the suitable cellphone floor receptors, their ligands, and their downstream pathways. additionally tested are the newest findings at the elements of novel signaling networks controlling the job of nuclear transcription components and mobilephone cycle regulatory molecules. state of the art and hugely suggestive, Signaling Networks and cellphone Cycle keep an eye on: The Molecular foundation of melanoma and different ailments offers a wealth of knowledge at the rising ideas of the sector, in addition to a useful advisor for all experimental and scientific investigators of phone law and its swiftly rising pharmacological possibilities this present day.
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Additional resources for Signaling networks and cell cycle control: the molecular basis of cancer and other diseases
Der 213 Page viii 13 Signaling Pathways Controlled by Rho Family GTP-Binding Proteins Marc Symons 231 14 PI3-Kinases: Role in Signal Transduction David A. Fruman and Lewis C. Cantley 247 15 PI3K-Related Kinases: Roles in Cell-Cycle Regulation and DNA Damage Responses Randal S. Tibbetts and Robert T. Abraham 267 16 Integrative Signaling Through c-Abl: A Tyrosine Kinase with Nuclear and Cytoplasmic Functions Jean Y. J. Wang 303 17 Src: A Model for Regulation of Intracellular Signaling Molecules Pamela L.
Farrell, 2000 6. Apoptosis and Cancer Chemotherapy, edited by John A. Hickman and Caroline Dive, 1999 5. Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, edited by J. Silvio Gutkind, 2000 4. Antifolate Drugs in Cancer Therapy, edited by Ann L. Jackman, 1999 3. Antiangiogenic Agents in Cancer Therapy, edited by Beverly A. Teicher, 1999 2. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, edited by Beverly A. Teicher, 1997 1.
Der 501 Page ix 29 Targeted p53 Gene Therapy-Mediated Radiosensitization and Chemosensitization Esther H. Chang, Liang Xu, and Kathleen F. Pirollo 519 30 Treatment of p53-Deficient Cancers by Adenovirus E1B-Region Mutants: From Basic Research to the Clinic David H. Kirn 537 31 The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention Michele Pagano and Katya Ravid 545 32 Chemical Cyclin-Dependent Kinase Inhibitors: Therapeutic Implications Edward A.